Dr Ben Seymour, Computational and Biological Learning Lab, Trumpington Street, Cambridge CB2 1PZ


Center for Information and Neural Networks, National Institute for Information and Communications Technology (NICT), 1-3 Yamadaoka, Suita, Osaka 565-0871, Japan.

bjs49 AT / seymour AT

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The puzzle of the putamen and pain.

Here's an extremely interesting study on the functional role of the putamen in pain processing - 'The contribution of the putamen to sensory aspects of pain: insights from structural connectivity and brain' by Starr and colleagues {1}.

The results are subtle. The extent to which it shows a role of the putamen in core sensory processing of pain is an interesting question. Consideration of the functional role of the putamen in behaviour in general suggests several possible mechanisms by which pain processing might be disrupted. First, we know the putamen plays a central role in dopamine-dependent reward value learning, and we know dopamine boosts sensory perceptual learning (e.g. improvements in tactile discrimination learning over time) {2}. Thus, perhaps the deficit here relates to a failure to improve performance in response to the task goal (which is by definition a reward). It would be interesting to know how performance changed over the course of the experiment. 

Second, we also know the ventral putamen is involved in pain (aversive) value learning from functional magnetic resonance imaging (fMRI) studies {3}, including our own {4}, so perhaps what it observed here is a reduction in the learned aversive response (emotional impact) of pain. It would be fascinating to test this possibility in a Pavlovian pain conditioning design.


1. Starr CJ, Sawaki L, Wittenberg GF, Burdette JH, Oshiro Y, Quevedo AS, McHaffie JG, Coghill RC. The contribution of the putamen to sensory aspects of pain: insights from structural connectivity and brain lesions. Brain. 2011 Jul; 134(Pt 7): 1987-2002.

 2. Influence of dopaminergically mediated reward on somatosensory decision-making. Pleger B, Ruff CC, Blankenburg F, Klöppel S, Driver J, Dolan RJPLoS Biol 2009 Jul; 7(7):e1000164 PMID: 19636360

3.Direct activation of the ventral striatum in anticipation of aversive stimuli.
Jensen J, McIntosh AR, Crawley AP, Mikulis DJ, Remington G, Kapur SNeuron 2003 Dec 18; 6(40):1251-7 
PMID: 14687557
4.Temporal difference models describe higher-order learning in humans.
Seymour B, O'Doherty JP, Dayan P, Koltzenburg M, Jones AK, Dolan RJ, Friston KJ, Frackowiak RSNature 2004 Jun 10; 6992(429):664-7 
PMID: 15190354

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